G Lippi et al, 2015, Venous thromboembolism and coffee: critical review and meta-analysis, Annals of Translational Medicine, Volume 3 (11).

ABSTRACT

BACKGROUND: Among the various risk factors of venous thromboembolism (VTE), nutrients seem to play a significant role in the pathogenesis of this condition. This study aimed to clarify the relationship between coffee intake and venous thrombosis, and we performed a critical review of clinical studies that have been published so far.

METHODS: An electronic search was carried out in Medline, Scopus and ISI Web of Science with the keywords “coffee” AND “venous thromboembolism” OR “deep vein thrombosis” OR “pulmonary embolism” in “Title/Abstract/Keywords”, with no language and date restriction.

RESULTS: According to our criteria, three studies (two prospective and one case-control) were finally selected (inter-study heterogeneity: 78%; P<0.001). Cumulative data suggests that a modest intake of coffee (i.e., 1-4 cups/day) may be associated with an 11% increased risk of VTE compared to abstainers, whereas a larger intake (i.e., ≥5 coffee/day) may be associated with a 25% decreased risk.

CONCLUSIONS: Our analysis of published data seemingly confirm the existence of a U-shape relationship between coffee intake and VTE, thus exhibiting a trend that overlaps with that previously reported for cardiovascular disease (CVD).

The post G Lippi et al, 2015, Venous thromboembolism and coffee: critical review and meta-analysis, Annals of Translational Medicine, Volume 3 (11). appeared first on Coffee and Health.

G Grosso et al, 2015, Coffee consumption and risk of hypertension in the Polish arm of the HAPIEE cohort study, European Journal of Clinical Nutrition, published online ahead of print.

ABSTRACT

BACKGROUND/OBJECTIVES: Coffee consumption has been hypothesized to be associated with blood pressure (BP), but previous findings are not homogeneous. The aim of this study was to evaluate the association between coffee consumption and the risk of developing hypertension.

SUBJECTS/METHODS: Data on coffee consumption, BP and use of anti-hypertensive medicament were derived from 2725 participants of the Polish arm of the HAPIEE project (Health, Alcohol and Psychosocial factors In Eastern Europe) who were free of hypertension at baseline and followed up for an average of 5 years. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by multivariate logistic regression analyses and stratified for potential confounding factors.

RESULTS: Coffee consumption was related to decreased age, smoking status and total energy intake. Compared with persons who drink <1 cup coffee per day, systolic BP was significantly associated with coffee consumption and the risk of hypertension was lower for individuals consuming 3–4 cups per day. Despite the analysis stratified by gender showed that the protective effect of coffee consumption on hypertension was significant only in women, the analysis after stratification by smoking status revealed a decreased risk of hypertension in non-smokers drinking 3–4 cups of coffee per day in both sexes (OR 0.41, 95% CI: 0.21, 0.79 for men and OR 0.54, 95% CI: 0.29, 0.99 for women). Upper category coffee consumption (>4 cups per day) was not related to significant increased risk of hypertension.

CONCLUSIONS: Relation between coffee consumption and incidence of hypertension was related to smoking status. Consumption of 3–4 cups of coffee per day decreased the risk of hypertension in non-smoking men and women only

The post G Grosso et al, 2015, Coffee consumption and risk of hypertension in the Polish arm of the HAPIEE cohort study, European Journal of Clinical Nutrition, published online ahead of print. appeared first on Coffee and Health.

V J A Verlinden et al, 2015, The association of alcohol, coffee and tobacco consumption with gait in a community-dwelling population, European Journal of Clinical Nutrition, published online ahead of print

ABSTRACT

BACKGROUND/OBJECTIVES: Gait is an important health indicator, relating strongly to the risk of falling, morbidity and mortality. In a community-dwelling population, we investigated associations of alcohol, coffee and tobacco consumption with gait.

SUBJECTS/METHODS: Two thousand forty-six non-demented participants from the Rotterdam Study underwent gait assessment by electronic walkway. We measured gait velocity and Global Gait, which is the average of seven gait domains: Rhythm, Phases, Variability, Pace, Tandem, Turning and Base of Support. Alcohol, coffee and tobacco consumption was assessed by questionnaires. With analysis of covariance, we investigated associations of consumption of alcoholic beverages, coffee consumption and smoking with Global Gait, gait velocity and the seven individual gait domains.

RESULTS: In all, 81.9% of participants drank alcohol, 92.4% drank coffee, 17.3% were current smokers and 50.9% were past smokers. Moderate alcohol consumption (1–3 glasses per day) associated with better gait, as measured by Global Gait (0.20 standard deviations (s.d.) (95% confidence interval: 0.10; 0.31)), gait velocity (2.65 cm/s (0.80; 4.50)), Rhythm and Variability. Consuming high amounts of coffee (43 cups per day) associated with better Global Gait (0.18 s.d. (0.08; 0.28)), gait velocity (2.63 cm/s (0.80; 4.45)), Pace, Turning and Variability. Current smoking associated with worse Global Gait (−0.11 s.d. (−0.21; 0.00)), gait velocity (−3.47 cm/s (−5.33; − 1.60)), Rhythm and Pace, compared with non-smokers.

CONCLUSIONS: In a community-dwelling population, consuming >1 cup of coffee and 1–3 glasses of alcohol relate to better gait, whereas smoking is related to worse gait. Further studies are required to evaluate whether interventions targeting substance consumption may aid to prevent or reduce gait deterioration and thereby related health problems.

The post V J A Verlinden et al, 2015, The association of alcohol, coffee and tobacco consumption with gait in a community-dwelling population, European Journal of Clinical Nutrition, published online ahead of print appeared first on Coffee and Health.

Y-P Zhang et al, 2015, Systematic review with meta-analysis: coffee consumption and the risk of gallstone disease, Alimentary Pharmacology & Therapeutics, published online ahead of print.

ABSTRACT:
BACKGROUND: Epidemiologic evidence on coffee consumption reducing the risk of gallstone disease has been contradictory.

AIM: To perform a meta-analysis of observational studies, to investigate an association and dose-response of coffee consumption with gallstone disease.

METHODS: We used PubMed and EMBASE databases to identify all published studies before June 2015. A random-effects model was used to compute a pooled relative risk (RR) and corresponding 95% confidence intervals (CIs).

RESULTS: One case-control study and five prospective cohort studies (with seven cohorts) involving 227 749 participants and 11 477 gallstone disease cases were included. Coffee consumption was significantly associated with a reduced risk of gallstone disease (RR, 0.83; 95% CI, 0.76 to 0.89; I2  = 35.9%), based on prospective studies; specifically, we observed an inverse relation in females, but not in males. The case-control study did not reveal any association between coffee and gallstone disease (OR, 0.99; 95% CI, 0.64 to 1.53). In a dose-response analysis, the RR of gallstone disease was 0.95 (95% CI, 0.91 to 1.00; P = 0.049) per 1 cup/day of coffee consumption. A significant nonlinear dose-response association was also identified (P for nonlinearity = 0.0106). For people who drank 2, 4 and 6 cups of coffee per day, the estimated RRs of gallstone disease were 0.89 (95% CI, 0.79 to 0.99), 0.81 (95% CI, 0.72 to 0.92) and 0.75 (95% CI, 0.64 to 0.88), respectively, compared with the lowest level drinkers.

CONCLUSION: This study suggests that coffee consumption is related to a significantly decreased risk of gallstone disease.

The post Y-P Zhang et al, 2015, Systematic review with meta-analysis: coffee consumption and the risk of gallstone disease, Alimentary Pharmacology & Therapeutics, published online ahead of print. appeared first on Coffee and Health.