OBJECTIVE: Serum levels of soluble TNF-like weak inducer of apoptosis (sTWEAK) and its scavenger receptor CD163 (sCD163) have been linked to insulin resistance. We analysed the usefulness of these cytokines as biomarkers of type 2 diabetes in a Spanish cohort, together with their relationship to food consumption in the setting of the Di@bet.es study.
RESEARCH DESIGN AND METHODS: This is a cross-sectional, matched case-control study of 514 type 2 diabetes subjects and 517 controls with a Normal Oral Glucose Tolerance Test (NOGTT), using data from the Di@bet.es study. Study variables included clinical and demographic structured survey, food frequency questionnaire and physical examination. Serum concentrations of sTWEAK and sCD163 were measured by ELISA. Linear regression analysis determined which variables were related to sTWEAK and sCD163 levels. Logistic regression analysis was used to estimate odd ratios of presenting type 2 diabetes.
RESULTS: sCD163 concentrations and sCD163/sTWEAK ratio were 11.0% and 15.0% higher, respectively, (P<0.001) in type 2 diabetes than in controls. Following adjustment for various confounders, the OR for presenting type 2 diabetes in subjects in the highest vs the lowest tertile of sCD163 was [(OR), 2,01 (95%CI, 1,46-2,97); P for trend <0.001]. Coffee and red wine consumption was negatively associated with serum levels of sCD163 (P = 0.0001 and; P = 0.002 for coffee and red wine intake, respectively).
CONCLUSIONS: High circulating levels of sCD163 are associated with type 2 diabetes in the Spanish population. The association between coffee and red wine intake and these biomarkers deserves further study to confirm its potential role in type 2 diabetes.
This review provides the epidemiologic and research evidences documenting the effects of coffee consumption on type 2 diabetes mellitus (T2DM). We summarize the literature concerning the effects of coffee consumption on different mechanistic factors involving in pathogenesis of T2DM, such as glucose tolerance, insulin sensitivity, insulin resistance, glucose-6-phosphatase, intestinal glucose absorption, antioxidant activity, inflammatory biomarkers, nuclear factor-κB inhibition, glucose uptake, glucose homeostasis, glucose metabolism, and insulin secretion. These factors play a crucial role in influencing the normal levels of glucose in blood. Overall, the experimental and epidemiologic evidences presented here elucidate the protective effects of coffee consumption on T2DM, involving multiple preventive mechanisms. Despite the firm evidences available through a growing literature base, it is still uncertain whether the use of coffee should be recommended to patients with diabetes and/or any patient who might be at the risk of T2DM as a supplementary therapy to prevent further progression of T2DM.
Amsterdam-based Frans Goddijn is one of specialty coffee’s mad scientists. Most recently, he’s shared with us his camera work capturing transparent portafilters to monitor puck behavior during extraction. Now Goddijn gives us his latest FrankenCoffee project: A decked out moka pot that he says results in a sweet espresso-like brew, including a touch of crema. “With a moka pot?” you ask. “Yes,” we say, […]
For the second year running, Nestlé Nespresso has looked to the academic business world for ideas to fold into the Swiss mega-roaster and pod-maker’s sustainability plans. Sustainability in the single-serve pod segment is arguably an oxymoronic concept, but if nothing else, the second annual Nespresso MBA Challenge gives the coffee world a fresh perspective on how some of the brightest minds in business […]
South Koreans are importing more roasted coffee from the United States, reflecting the popularity of U.S. brands, as well as relaxed trade taxes. The amount of roasted coffee imported by South Korea from the United States saw a double-digit annual increase in 2013, according to data released July 4 by the Korea Customs Service and obtained by multiple Korean news outlets. […]
Previous studies have examined whether or not an association exists between the consumption of caffeinated coffee to all-cause and cardiovascular mortality. This study aimed to delineate this association using population representative data from the National Health and Nutrition Examination Survey III. Patients were included in the study if all the following criteria were met: (1) follow-up mortality data were available, (2) age of at least 45 years, and (3) reported amount of average coffee consumption. A total of 8608 patients were included, with patients stratified into the following groups of average daily coffee consumption: (1) no coffee consumption, (2) less than 1 cup, (3) 1 cup a day, (4) 2-3 cups, (5) 4-5 cups, (6) more than 6 cups a day. Odds ratios, 95% confidence intervals, and P values were calculated for univariate analysis to compare the prevalence of all-cause mortality, ischemia-related mortality, congestive heart failure-related mortality, and stroke-related mortality, using the no coffee consumption group as reference. These were then adjusted for confounding factors for a multivariate analysis. P < 0.05 were considered statistically significant. Univariate analysis demonstrated an association between coffee consumption and mortality, although this became insignificant on multivariate analysis. Coffee consumption, thus, does not seem to impact all-cause mortality or specific cardiovascular mortality. These findings do differ from those of recently published studies. Coffee consumption of any quantity seems to be safe without any increased mortality risk. There may be some protective effects but additional data are needed to further delineate this.
OBJECTIVE: Coffee and tea consumption is associated with a decreased type 2 diabetes risk in non-pregnant adults. We examined the relation between first trimester coffee and tea consumption and gestational diabetes mellitus (GDM) risk.
DESIGN: Population-based cohort study.
SETTING: Denmark 1996-2002.
POPULATION: Non-diabetic women with singleton pregnancies in the Danish National Birth Cohort (n = 71 239).
METHODS: Estimated adjusted relative risks (RR) and 95% confidence intervals (95%CI) for the association between first trimester coffee and tea or estimated total caffeine and GDM.
MAIN OUTCOME MEASURES: GDM ascertained from the National Hospital Discharge Register or maternal interview.
RESULTS: Coffee or tea intake was reported in 81.2% (n = 57 882) and 1.3% (n = 912) of pregnancies were complicated by GDM. Among non-consumers, 1.5% of pregnancies were complicated by GDM. Among coffee drinkers, GDM was highest among women who drank ≥8 cups/day (1.8%) with no significant difference across intake levels (P = 0.10). Among tea drinkers, there was no difference in GDM across intake levels (1.2%; P = 0.98). After adjustment for age, socio-occupational status, parity, pre-pregnancy body mass index, smoking, and cola, there was suggestion of a protective, but non-significant association with increasing coffee (RR ≥8 versus 0 cups/day = 0.89 [95%CI 0.64-1.25]) and tea (RR ≥8 versus 0 cups/day = 0.77 [95%CI 0.55-1.08]). Results were similar by smoking status, except a non-significant 1.45-fold increased risk with ≥8 coffee cups/day for non-smokers. There was a non-significant reduced GDM risk with increasing total caffeine.
CONCLUSIONS: Our results suggest that moderate first trimester coffee and tea intake were not associated with GDM increased risk and possibly may have a protective effect.
A service to the entire specialty coffee world, SCAA Symposium has been releasing a number videos from the most recent Symposium in April. Latest in the series came July 2, featuring Gail Vance Civille of Sensory Spectrum, Inc., who has been tasting professionally for nearly 50 years. (related: Slurping in Context: A Look at Intelligentsia’s New Cupping Form) Far less an educational seminar than […]
The concept of relationships in coffee is a huge one, applying to any combination of people including farmers, importers, buyers, roasters and consumers. But the coffee is always the tie that binds. Rarely is the concept of coffee relationships manifested so perfectly as in the case of Kapo Chiu, the owner of Hong Kong’s The Cupping Room, who recently placed second […]
There are reasons some flavor combinations have never been brought to market. Nonetheless, Miami-based Friends Fun Wine — the makers of the 6% ABV “Fun Wine in a Can,” with products like Stawberry Moscato and Red Sangria — is introducing the world to coffee wine. The company, which markets its canned wines as lifestyle products for bikini-clad poolside types, says its […]