From the shining sea to quieter amber waves of grain, Brad Penna and Nam Ho moved from Southern California to Iowa last year on a quest to open a coffee bar and roastery in…
After years of developing commercial roasting skills, along with an appreciation for sustainable sourcing methods that benefit coffee farming communities, Hans Hochstedler and wife Joelle Hochstedler have launched a quality-focused new micro roastery in Columbus,…
One of the earliest and biggest successes in today’s now crowded RTD cold coffee category, Austin, Texas-based Chameleon Cold Brew has just branched out with new products aimed at changing public…
After some merging, reshuffling and kink-ironing in relation to its sustainability efforts following the SCAA/SCAE merger, the unified Specialty Coffee Association is launching a new sustainability conference called Avance. Importantly,…
In 1991, coffee was classified as a group 2B carcinogen, possibly carcinogenic to humans, based on limited epidemiologic evidence of a positive association with bladder cancer. In 2016, the International Agency for Research on Cancer downgraded this classification due to lack of evidence from prospective studies particularly for never smokers.
Baseline coffee drinking was assessed with a food frequency questionnaire in the NIH-AARP prospective cohort study. Among 469,047 US adults, who were cancer free at baseline, 6,012 bladder cancer cases (5,088 men and 924 women) were identified during >6.3 million person-years of follow-up. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI), with non-coffee drinkers as the reference group.
Coffee drinking was positively associated with bladder cancer in models adjusted for age and sex (HR for ≥4 cups/d relative to coffee nondrinkers = 1.91, 95% CI = 1.70, 2.14; P trend < 0.0001). However, the association was substantially attenuated after adjustment for cigarette smoking and other potential confounders (HR for ≥4 cups/d relative to coffee nondrinkers = 1.18, 95% CI = 1.05, 1.33; P trend = 0.0007). Associations were further attenuated after additional adjustment for lifetime smoking patterns among the majority of the cohort with this available data (P trend = 0.16). There was no evidence of an association among never smokers (P trend = 0.84).
Positive associations between coffee drinking and bladder cancer among ever smokers but not never smokers suggest that residual confounding from imperfect measurement of smoking or unmeasured risk factors may be an explanation for our positive findings.
The post E Loftfield et al, 2017. A Prospective Investigation of Coffee Drinking and Bladder Cancer Incidence in the United States, Epidemiology, Volume 28. appeared first on Coffee and Health.
This report evaluates the scientific literature on caffeine with respect to potential cardiovascular outcomes, specifically relative risks of total cardiovascular disease (CVD), coronary heart disease (CHD) and acute myocardial infarction (AMI), effects on arrhythmia, heart failure, sudden cardiac arrest, stroke, blood pressure, hypertension, and other biomarkers of effect, including heart rate, cerebral blood flow, cardiac output, plasma homocysteine levels, serum cholesterol levels, electrocardiogram (EKG) parameters, heart rate variability, endothelial/platelet function and plasma/urine catecholamine levels. Caffeine intake has been associated with a range of reversible and transient physiological effects broadly and cardiovascular effects specifically. This report attempts to understand where the delineations exist in caffeine intake and corresponding cardiovascular effects among various subpopulations. The available literature suggests that cardiovascular effects experienced by caffeine consumers at levels up to 600 mg/day are in most cases mild, transient, and reversible, with no lasting adverse effect. The point at which caffeine intake may cause harm to the cardiovascular system is not readily identifiable in part because data on the effects of daily intakes greater than 600 mg is limited. However, the evidence considered within this review suggests that typical moderate caffeine intake is not associated with increased risks of total cardiovascular disease; arrhythmia; heart failure; blood pressure changes among regular coffee drinkers; or hypertension in baseline populations.
The post D Turnbull et al, 2017. Caffeine and Cardiovascular Health, Regulatory Toxicology and Pharmacology, Volume 89. appeared first on Coffee and Health.
Caffeine, 1,3,7-trimethylxanthine, is widely consumed by women of reproductive age. Although caffeine has been proposed to inhibit fetal growth, previous studies on the effects of caffeine on infant birth size have yielded inconsistent findings. This inconsistency may result from failure to account for individual differences in caffeine metabolism related to polymorphisms in the gene for CYP1A2, the major caffeine-metabolizing enzyme.
Five hundred fourteen Japanese women participated in a prospective cohort study in Sapporo, Japan, from 2002 to 2005, and 476 mother-child pairs were included for final analysis.
Caffeine intake was not significantly associated with mean infant birth size. When caffeine intake and CYP1A2 C164A genotype were considered together, women with the AA genotype and caffeine intake of ≥300 mg per day had a mean reduction in infant birth head circumference of 0.8 cm relative to the reference group after adjusting for confounding factors. In a subgroup analysis, only nonsmokers with the AA genotype and caffeine intake of ≥300 mg per day had infants with decreased birth weight (mean reduction, 277 g) and birth head circumference (mean reduction, 1.0 cm).
Nonsmokers who rapidly metabolize caffeine may be at increased risk for having infants with decreased birth size when consuming ≥300 mg of caffeine per day.
The post S Sasaki et al, 2017. Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study, Pediatric Research, Volume 82 (1) appeared first on Coffee and Health.
Chicago-based Intelligentsia Coffee has just opened its first retail coffee bar in the Boston market, adjacent to its third training lab facility on the East Coast. The 1,500-square-foot retail space,…
Opening next month in Downtown Los Angeles is a roastery café a half-century in the making. Don Francisco’s Coffee — a brand owned by Vernon, Calif.-based F. Gaviña & Sons,…
In collaboration with the nonprofit International Women’s Coffee Alliance (IWCA), Nevada-based coffee roasting and brewing equipment manufacturer Behmor has pledged to donate equipment to reach female producers in 21 IWCA chapters…