S Rabiepoor et al, 2017. Does coffee affect the bowel function after caesarean section? Eur J Obstet Gynecol Reprod Biol, published online.

ABSTRACT:

OBJECTIVES:
Postoperative ileus is a common consequence of abdominal surgery, which tends to prolong the duration of hospital stay and imposes considerable economic costs on healthcare system. Coffee is proved to have positive effects on gastrointestinal motility index in healthy young adults. Thus, the present study aims to examine effects of coffee on bowel function after caesarean section.

MATERIAL AND METHOD:
A total number 100 patients after elective caesarean section were randomly assigned before surgery into control and intervention groups. The intervention group received 100cc coffee at 8, 12 and 20h after the surgery, while the control group received 100cc hot water at the same intervals. First bowel sound, first passage of flatus, first defecation, and length of stay after surgery were compared in the two groups.

FINDINGS:
Mean time to first flatus passage was recorded in the control (22.54±5.09h) and intervention (17.28±4.44h) groups and showed to be statistically significant (p=-0.000). However, average time of first defecation (intervention 37.22±16.31h; control 36.82±16.5h; p=0.647) and mean time of hospital stay of patients (intervention 30.08±9.50h; control 32.16±11.82h; p=0.518) and first bowel sound (intervention 5.84±1.41h; control 6.16±1.33h; p=-0.326) were not statistically significant.

DISCUSSION:
Drinking coffee after a caesarean section reduces time to first flatus in patients. Nevertheless, further studies are needed to examine effects of coffee on ileus after elective caesarean section.

The post S Rabiepoor et al, 2017. Does coffee affect the bowel function after caesarean section? Eur J Obstet Gynecol Reprod Biol, published online. appeared first on Coffee and Health.

J-S Ong et al 2017. Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study, International Journal of Epidemiology, published online.

ABSTRACT

BACKGROUND:
Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.

METHODS:
We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator.

RESULTS:
For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases.

CONCLUSIONS:
We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations

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Y Hu et al, 2017. Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced Mortality. Gastroenterology, published online.

ABSTRACT

BACKGROUND & AIMS: Few studies have examined the association between coffee intake and survival after diagnosis of colorectal cancer (CRC). We performed a prospective study to investigate the association between coffee intake after a diagnosis of CRC and mortality.

METHODS: We collected data from the Nurses’ Health Study (1984-2012) and Health Professionals Follow-up Study (1986-2012), following 1599 patients diagnosed with stage 1 or 2 CRC. CRC was reported on questionnaires and ascertained by review of medical records and pathology reports; intake of food and beverages was determined from responses to semi-quantitative food frequency questionnaires. Participants were asked how often during the previous year that they consumed coffee, with 1 cup as the standard portion size. The first questionnaire response collected at least 6 months but not more than 4 years after diagnosis was used for assessment of post-diagnostic intake (median time from diagnosis to the dietary assessment, 2.2 years). The last sFFQ prior to diagnosis was used to assess pre-diagnostic dietary intake.

RESULTS: During a median of 7.8 years of follow-up, we documented 803 deaths, of which 188 were due to CRC. In the multivariable adjusted models, compared with nondrinkers, patients who consumed at least 4 cups of coffee per day had a 52% lower risk of CRC-specific death (hazard ratio [HR] 0.48; 95% CI, 0.28-0.83; P for trend=.003) and 30% reduced risk of all-cause death (HR, 0.70; 95% CI, 0.54-0.91; P for trend <.001). High intake of caffeinated and decaffeinated coffee (2 or more cups/day) was associated with lower risk of CRC-specific mortality and all-cause mortality. When coffee intake before vs after CRC diagnosis were examined, compared with patients consistently consuming low amounts (less than 2 cups/day), those who maintained a high intake (2 or more cups/day) had a significantly lower risk of CRC-specific death (multivariable HR, 0.63; 95% CI, 0.44-0.89) and death from any cause (multivariable HR, 0.71; 95% CI, 0.60-0.85).

CONCLUSIONS: In an analysis data from the Nurses’ Health Study and Health Professionals Follow-up Study, we associated intake of caffeinated and decaffeinated coffee after diagnosis of CRC with lower risk of CRC-specific death and overall death. Studies are needed to determine the mechanisms by which coffee might reduce CRC progression.

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